全文获取类型
收费全文 | 742篇 |
免费 | 40篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 15篇 |
妇产科学 | 7篇 |
基础医学 | 74篇 |
口腔科学 | 20篇 |
临床医学 | 54篇 |
内科学 | 116篇 |
皮肤病学 | 124篇 |
神经病学 | 34篇 |
特种医学 | 12篇 |
外科学 | 109篇 |
综合类 | 18篇 |
预防医学 | 39篇 |
眼科学 | 22篇 |
药学 | 57篇 |
中国医学 | 11篇 |
肿瘤学 | 54篇 |
出版年
2023年 | 12篇 |
2022年 | 14篇 |
2021年 | 36篇 |
2020年 | 28篇 |
2019年 | 26篇 |
2018年 | 33篇 |
2017年 | 21篇 |
2016年 | 23篇 |
2015年 | 23篇 |
2014年 | 37篇 |
2013年 | 41篇 |
2012年 | 53篇 |
2011年 | 67篇 |
2010年 | 26篇 |
2009年 | 20篇 |
2008年 | 32篇 |
2007年 | 41篇 |
2006年 | 26篇 |
2005年 | 37篇 |
2004年 | 33篇 |
2003年 | 15篇 |
2002年 | 22篇 |
2001年 | 16篇 |
2000年 | 12篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 9篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1982年 | 6篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有784条查询结果,搜索用时 15 毫秒
91.
Sharmela Sahathevan Ban-Hock Khor Birinder Kaur Sadu Singh Alice Sabatino Enrico Fiaccadori Zulfitri Azuan Mat Daud Mohammad Syafiq Ali Sreelakshmi Sankara Narayanan Dina Tallman Karuthan Chinna Bak-Leong Goh Abdul Halim Abdul Gafor Ghazali Ahmad Zaki Morad Pramod Khosla Tilakavati Karupaiah 《Nutrients》2020,12(11)
This study aimed to assess muscle wasting and risk of protein energy wasting (PEW) in hemodialysis (HD) patients using an ultrasound (US) imaging method. PEW was identified using the ISRNM criteria in 351 HD patients. Quadriceps muscle thickness of rectus femoris (RF) and vastus intermedius (VI) muscles and cross-sectional area (CSA) of the RF muscle (RFCSA) were measured using US and compared with other physical measures. Associations of US indices with PEW were determined by logistic regression. Irrespective of gender, PEW vs. non-PEW patients had smaller RF, VI muscles, and RFCSA (all p < 0.001). US muscle sites (all p < 0.001) discriminated PEW from non-PEW patients, but the RFCSA compared to bio-impedance spectroscopy had a greater area under the curve (AUC, 0.686 vs. 0.581), sensitivity (72.8% vs. 65.8%), and specificity (55.6% vs. 53.9%). AUC of the RFCSA was greatest for PEW risk in men (0.74, 95% CI: 0.66–0.82) and women (0.80, 95% CI: 0.70–0.90) (both p < 0.001). Gender-specific RFCSA values (men < 6.00 cm2; women < 4.47 cm2) indicated HD patients with smaller RFCSA were 8 times more likely to have PEW (AOR = 8.63, 95% CI: 4.80–15.50, p < 0.001). The US approach enabled discrimination of muscle wasting in HD patients with PEW. The RFCSA was identified as the best US site with gender-specific RFCSA values to associate with PEW risk, suggesting potential diagnostic criteria for muscle wasting. 相似文献
92.
Hasliana Azrah Ab-Rahman Hafiz Rahim Sazaly AbuBakar Pooi-Fong Wong 《International journal of medical sciences》2016,13(3):179-186
Hemophagocytosis, a phenomenon of which activated macrophages phagocytosed hematopoietic elements was reportedly observed in severe dengue patients. In the present study, we investigated whether markers of macrophage activation syndrome (MAS) can be used as differential diagnostic markers of severe dengue. Two hundred and eight confirmed dengue patients were recruited for the study. Sandwich ELISA was used to determine serum ferritin, soluble CD163 (sCD163), and soluble CD25 (sCD25) levels. The population of circulating CD163 (mCD163) monocytes was determined using flow cytometry. Receiver operating characteristic (ROC) analysis was plotted to determine the predictive validity of the biomarkers. Serum ferritin and sCD163 were found significantly increased in severe dengue patients compared to dengue fever patients (P = 0.003). A fair area under ROC curves (AUC) at 0.72 with a significant P value of 0.004 was observed for sCD163. sCD25 and mCD163 levels were not significantly different between severe dengue and dengue fever patients. Our findings suggest that in addition to serum ferritin, sCD163 can differentiate severe dengue from that of dengue fever patients. Hence, sCD163 level can be considered for use as a predictive marker for impending severe dengue. 相似文献
93.
R. M. R. Pereira MD R. M. Daud W. C. Messina R. M. Oliveira W. Cossermelli 《Clinical rheumatology》1992,11(1):112-115
Summary Although vasculitidis may involve several organs and tissues, ureteral involvement is rare. The present report describes a case of a female child with ureteral stenosis in whom a diagnosis of necrotizing vasculitis was made. 相似文献
94.
The effect of total prohibition imposed in Bihar State with effect from April, 1979, was assessed on the basis of the hospital records of Patna Medical College Hospital. During the first seven months of prohibition, there was a significant decrease in the number of alcohol intoxication cases as compared to the numbers of such cases during the corresponding periods of 1976, 1977 and 1978 (P < 0.001). During the subsequent Jive months of prohibition the number of cases increased and the figure was not significantly different from those of previous years (P. > 0.07). Age, sex and urban or rural distributions of cases remained unaltered during prohibition and pre-prohibition periods. A similar trend was observed in Pilgrim Hospital, Goya which is situated 92 km south of Patna. There was however a significant decrease in alcohol related crimes during prohibition compared to previous years (P. < 0.01), and possible reasons for discrepancy between the hospital and arrest indicator are discussed. During the prohibition period there was a 20 per cent increase in illicit trade in liquor. While people from the lower income group favoured prohibition, those from the higher income group did not approve of it. People from both groups got alcohol in the black market. Except for the initial drop in the number of hospital cases, the medical problem of alcohol intoxication was not solved by the ineffective enforcement of prohibition. 相似文献
95.
96.
97.
98.
Khalid MH Akhtar MN Mohamad AS Perimal EK Akira A Israf DA Lajis N Sulaiman MR 《Journal of ethnopharmacology》2011,137(1):345-351
Ethnopharmacological relevance
Zingiber zerumbet (L.) Smith, a wild edible ginger species or locally known as “lempoyang”, commonly used in the Malays traditional medicine as an appetizer or to treat stomachache, toothache, muscle sprain and as a cure for swelling sores and cuts.Aim
The present study was conducted to investigate the possible mechanism of actions underlying the systemic antinociception activity of the essential oil of Zingiber zerumbet (EOZZ) in chemical-induced nociception tests in mice.Materials and methods
Acetic acid-induced abdominal constriction, capsaicin-, glutamate- and phorbol 12-myristate 13-acetate-induced paw licking tests in mice were employed in the study. In all experiments, EOZZ was administered systemically at the doses of 50, 100, 200 and 300 mg/kg.Results
It was shown that EOZZ given to mice via intraperitoneal and oral routes at 50, 100, 200 and 300 mg/kg produced significant dose dependent antinociception when assessed using acetic acid-induced abdominal writing test with calculated mean ID50 values of 88.84 mg/kg (80.88-97.57 mg/kg) and 118.8 mg/kg (102.5-137.8 mg/kg), respectively. Likewise, intraperitoneal administration of EOZZ at similar doses produced significant dose dependent inhibition of neurogenic pain induced by intraplantar injection of capsaicin (1.6 μg/paw), glutamate (10 μmol/paw) and phorbol 12-myristate 13-acetate (1.6 μg/paw) with calculated mean ID50 of 128.8 mg/kg (118.6-139.9 mg/kg), 124.8 mg/kg (111.4-139.7 mg/kg) and 40.29 (35.39-45.86) mg/kg, respectively. It was also demonstrated that pretreatment with l-arginine (100 mg/kg, i.p.), a nitric oxide precursor significantly reversed antinociception produced by EOZZ suggesting the involvement of l-arginine/nitric oxide pathway. In addition, methylene blue (20 mg/kg, i.p.) significantly enhanced antinociception produced by EOZZ. Administration of glibenclamide (10 mg/kg, i.p.), an ATP-sensitive K+ channel antagonist significantly reversed antinociceptive activity induced by EOZZ.Conclusion
Together, the present results suggested that EOZZ-induced antinociceptive activity was possibly related to its ability to inhibit glutamatergic system, TRPV1 receptors as well as through activation of l-arginine/nitric oxide/cGMP/protein kinase C/ATP-sensitive K+ channel pathway. 相似文献99.
Tham CL Lam KW Rajajendram R Cheah YK Sulaiman MR Lajis NH Kim MK Israf DA 《European journal of pharmacology》2011,652(1-3):136-144
100.
Mahmud O Dates C Akil L Ahmad HA 《International journal of environmental research and public health》2011,8(6):2524-2532
Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) are two catastrophic diseases affecting millions of people worldwide every year; and are considered to be pandemic by the World Health Organization. This study aims to compare the recent trends in TB and HIV in the United States and Sub-Saharan African Countries. Data (incidence, prevalence and death rates of HIV and TB) for the United States, Cameroon, Nigeria, and South Africa were collected from The Joint United Nations Programme for HIV/AIDS (UNAIDS), US Census Bureau and World Health Organization (WHO) databases and analyzed using Statistical Analysis Software (SAS v 9.1). Analysis of Variance (ANOVA) was performed to compare the variables of interest between the countries and across time. Results showed that percent rates of TB cases, TB deaths, HIV cases and HIV deaths were significantly different (P<0.001) among these countries from 1993 to 2006. South Africa had the highest rates of HIV and TB; while US had the lowest rates of both diseases. Tuberculosis and HIV rates for Cameroon and Nigeria were significantly higher when compared to the United States, but were significantly lower when compared to South Africa (P<0.001). There were significant differences (P<0.001) in the prevalence of TB and HIV between the United States and the Sub-Saharan African countries, as well as differences within the Sub-Saharan African countries from 1993 to 2006. More analysis needs to be carried out in order to determine the prevalence and incidence of HIV and TB among multiple variables like gender, race, sexual orientation and age to get a comprehensive picture of the trends of HIV and TB. 相似文献